This role of WDR46 is enabled by its interaction property via intrinsically disordered regions. They act transiently to help in the proper assembly of coat protein shells and in the tailed-phage cases in the determination of the one unique vertex (above). These findings suggest a structural role for WDR46 in organizing the 18S ribosomal RNA processing machinery. Biology Professor (Twitter: DrWhitneyHolden) explains the four major functions of scaffold proteins (or scaffolding proteins) in a cell's signalling pathways. Scaffolding proteins are proteins that assemble in fairly large numbers into procapsids but are not present in the completed virion. This is because the proper recruitment of nucleolin and DDX21 to the nucleoli in daughter cells after cell division is ensured by WDR46. If similar ultrasensitive mechanisms occur in mammalian. These proteins usually have many protein binding domains (like WD40 repeats). The scaffold protein Ste5, which binds MAPK cascade components in an active complex, is the direct modulator of the pheromones action. When WDR46 was knocked down, two of its binding partners, nucleolin and DDX21 (involved in 18S rRNA processing), were mislocalized from the granular component to the edges of the nucleoli, whereas other binding partners, NOP2 and EBP2 (involved in 28S rRNA processing), were not affected. Reactions known to consume the compound: 2Fe-2S iron-sulfur cluster biosynthesis : an S-sulfanyl-cysteine. A protein whose main function is to bring other proteins together for them to interact. The N- and C-terminal regions of WDR46 are predicted to be intrinsically disordered, and both regions are critical for the nucleolar localization of WDR46 and the association with its binding partners.

WDR46 is a highly insoluble nucleolar protein, and its subcellular localization is dependent on neither DNA nor RNA. In this study, we showed that one of the nuclear scaffold proteins, WDR46, plays a role as a fundamental scaffold component of the nucleolar structure. The eukaryotic nucleus is a membrane-enclosed compartment supported by a complex scaffold or matrix of non-histone proteins (Podgornaya et al., 2003).Some nuclear scaffold proteins leave the nucleus at the time of nuclear envelope breakdown and are targeted to various mitotic apparati (Nickerson et al., 1992 Compton et al. The nuclear scaffold is an insoluble nuclear structure that contributes to the inner nuclear organization. Synonym(s) : malcavernin, MGC4607, OSM, osmosensing scaffold for MEKK3 Previous symbols and names : C7orf22, CCM2 scaffolding protein, cerebral cavernous.

Scaffold protein